cGMP-Dependent Protein Kinase I and Smooth Muscle Relaxation
نویسندگان
چکیده
منابع مشابه
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
The maintenance of vascular tone is central to the regulation of blood pressure and tissue perfusion and plays a role in the pathogenesis of hypertension and atherosclerosis. Vascular tone is determined by the balance of vasodilator and vasoconstrictor stimuli. After several decades of research, the NO/cGMP/cGMP-dependent protein kinase (cGK) pathway is now recognized as an important mediator o...
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s: Weinmeister P., Lukowski R., Linder S., Feil S., Hofmann F., Feil R. (2006). DieWachstumsregulation durch zyklische Nukleotide unterscheidet sich in primären undsubkultivierten glatten Gefäßmuskelzellen. 47. Frühjahrstagung der DGPT. (Mainz,Germany) Lukowski R., Weinmeister P., Feil S., Gotthardt M., Herz J., Massberg S., Hofmann F., FeilR. (2006). Bedeutung des cGMP/cGMP-abh...
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The cGMP-dependent protein kinase type I (cGKI) is a major mediator of NO/cGMP-induced vasorelaxation. Smooth muscle expresses two isoforms of cGKI, cGKIalpha and cGKIbeta, but the specific role of each isoform in vascular smooth muscle cells (VSMCs) is poorly understood. We have used a genetic deletion/rescue strategy to analyze the functional significance of cGKI isoforms in the regulation of...
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Cyclic GMP modulates gene expression in vascular smooth muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphorylation of transcription factors. In some cells, cGMP increases nuclear translocation of PKGI and PKGI-dependent phosphorylation of transcription regulators; however, these observations have been variable, and the mechanisms mediating nuclear ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.165779